[A case of advanced sigmoid colon cancer performed resection of liver metastases after long-term control by S-1 and CPT-11 combination chemotherapy].

Abstract

A 60-year-old man diagnosed as advanced sigmoid colon cancer was performed sigmoidectomy and D3 lymph node dissection. Intra-operative findings were SE, P0H1N4M (-), and Stage IV. One month after the operation, we started a combination chemotherapy using S-1 plus CPT-11 as one course for five weeks. S-1 (120 mg/body/day) was orally administered continuously for 3 weeks, and CPT-11 (80 mg/m2) was done intravenously on days 1 and 15. A Follow-up abdominal CT scan revealed a drastic reduction of liver metastasis and disappearance of para-aortic lymph node swelling (PR in). The combination chemotherapy was once finished after eight courses due to the patient's request. However, we started to administer the same regimen to him again six months later because of re-growth of liver metastasis. An additional six-course administration resulted in a reduction of liver metastasis by CT scan, and no other abnormal concentration besides two liver metastases by PET-CT examination was observed, and we performed a partial resection (two parts) of the liver and cholecystectomy 24 months after the first operation. The patient has been alive with disease free for five months since the second operation.

• Authors: Shu Okamura, Ken Nakata, Rei Suzuki, Kumiko Uji, Atsuko Yoshida, Mio Yoshimura, Kaoru Okada, Shin Nakahira, Hirofumi Miki, Keishi Sugimoto, Shigeyuki Tamura
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 35 Issue 12 Pg. 2168-70 (Nov 2008) ISSN: 0385-0684 [Print] Japan
• PMID: 19106559 (Publication Type: Case Reports, Journal Article)

Chemical References

• Carcinoembryonic Antigen
• Drug Combinations
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Irinotecan
• Camptothecin

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Camptothecin (analogs & derivatives, therapeutic use)
• Carcinoembryonic Antigen (blood)
• Drug Combinations
• Humans
• Irinotecan
• Liver Neoplasms (blood, drug therapy, secondary, surgery)
• Male
• Middle Aged
• Neoplasm Staging
• Oxonic Acid (therapeutic use)
• Positron-Emission Tomography
• Sigmoid Neoplasms (blood, drug therapy, pathology, surgery)
• Tegafur (therapeutic use)
• Time Factors
• Tomography, X-Ray Computed