[Mildronate effects on oxidant stress in type 2 diabetic patients with diabetic peripheral (sensomotor) neuropathy].

Abstract

AIM:

To clarify mildronate effects on oxidant stress and tissue oxygen in combined treatment of peripheral (sensomotor) neuropathy in patients with type 2 diabetes mellitus (DM).

MATERIAL AND METHODS:

An open randomized trial investigated 70 matched patients with type 2 DM and sensomotor neuropathy. They were randomized into two groups. The study group received basic anti-diabetic treatment, alpha-lipoic acid and mildronate for 3 months. Patients of the control group received the same treatment but mildronate.

RESULTS:

Mildronate administration improved clinical condition of the study group patients vs controls by neuropathy and symptoms count scales, electrophysiological properties of the nerve fibers, optimization of oxygen tissue balance, reduced production of lipid peroxidation products and activated enzymes of antioxidant defense.

CONCLUSION:

It is recommended to add 1 g/day mildronate to standard schemes of treatment for diabetes and sensomotor neuropathy.

• Authors: M E Statsenko, L V Poletaeva, S V Turkina, A F Apukhtin, G P Dudchenko
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 80 Issue 10 Pg. 27-30 ( 2008) ISSN: 0040-3660 [Print] Russia (Federation)
• PMID: 19105409 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Cardiovascular Agents
• Methylhydrazines
• 3-(2,2,2-trimethylhydrazine)propionate

Topics

• Aged
• Cardiovascular Agents (therapeutic use)
• Diabetes Mellitus, Type 2 (blood, drug therapy, epidemiology)
• Diabetic Neuropathies (epidemiology)
• Fasting
• Female
• Humans
• Male
• Methylhydrazines (therapeutic use)
• Middle Aged
• Oxidative Stress (drug effects)