Differential effect of L-threo-3,4-dihydroxyphenylserine in pure autonomic failure and multiple system atrophy with autonomic failure.

Abstract

Treatment with L-threo-3,4-dihydroxyphenylserine (L-threo-dops), a synthetic precursor of norepinephrine, significantly increased upright blood pressure in patients with multiple system atrophy but had no effect on the upright blood pressure of patients with pure autonomic failure. These results suggest that the site of action of L-threo-dops is central and that its pressor effect requires intact peripheral sympathetic neurons.

• Authors: H Kaufmann, E Oribe, M D Yahr
• Journal: Journal of neural transmission. Parkinson's disease and dementia section (J Neural Transm Park Dis Dement Sect) Vol. 3 Issue 2 Pg. 143-8 ( 1991) ISSN: 0936-3076 [Print] Austria
• PMID: 1910486 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Droxidopa
• Norepinephrine

Topics

• Adult
• Aged
• Atrophy
• Autonomic Nervous System Diseases (pathology, physiopathology)
• Blood Pressure (drug effects)
• Droxidopa (pharmacology)
• Humans
• Hypotension, Orthostatic
• Kinetics
• Middle Aged
• Norepinephrine (blood)
• Supine Position