This study was a prospective, randomized clinical trial carried out to explore the efficacy of payayor in the prevention and relief of radiation-induced
oral mucositis compared with
benzydamine. Sixty patients with
head and neck cancer, who have started to receive
radiotherapy and met predetermined criteria, were randomly assigned into each group to use assigned products 3 times a day from the first to the last day of radiation. The first group used
glycerin payayor, a Thai prepared herbal product, by dripping it into the mouth. Another group rinsed their mouths with
benzydamine hydrochloride. The World Health Organization
Mucositis Grading System was used to assess oral status every week and 2 weeks after radiation. Comparison of time to the onset,
pain, severity,
xerostomia, postponement of treatment, satisfaction of the
solution, and
body weight between the 2 groups was performed by t test. The average time to the onset of
oral mucositis in the payayor group was significantly later, and its severity and
pain score were less than those of the
benzydamine group throughout the study period. Significantly higher satisfaction with the
solution and higher
body weight at the end of the study were shown in the payayor group. Payayor seemed to be superior to
benzydamine for preventing and relieving radiation-induced
oral mucositis.