Comparison of a cytokine adsorbing column and an endotoxin absorbing column for the treatment of experimental endotoxemia.

Abstract

The present study compared the effects of direct hemoperfusion (DHP) using a cytokine absorbing (CTR) column with those using an endotoxin absorbing (PMX) column with endotoxin-induced shock in rats. Thirty-six rats were injected intravenously with endotoxin (15 mg/kg), and then allocated into one of the following three groups: control group, treated without CTR; PMX group, treated with a PMX column for 120 min; CTR group, treated with a CTR column for 120 min. The present study showed that CTR treatment decreased the mortality rate 8h after endotoxin injection and inhibited inflammatory responses (cytokine, hemodynamics and acidosis) similar to PMX treatment.

• Authors: Takumi Taniguchi, Akihide Kurita, Ken Yamamoto, Hideo Inaba
• Journal: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis (Transfus Apher Sci) Vol. 40 Issue 1 Pg. 55-9 (Feb 2009) ISSN: 1473-0502 [Print] England
• PMID: 19103510 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cytokines
• Endotoxins

Topics

• Absorption
• Animals
• Cytokines
• Disease Models, Animal
• Endotoxemia (chemically induced, therapy)
• Endotoxins (toxicity)
• Hemoperfusion (instrumentation, methods)
• Male
• Rats
• Rats, Wistar