Abstract | OBJECTIVES: METHODS AND RESULTS: We performed a mass spectrometry-based analysis of ADMA and SDMA in the plasma of 572 participants of the Bruneck study. Levels of ADMA and SDMA were significantly correlated with each other (r=0.189, p<0.001). Age and parameters of renal function, however, showed a stronger influence on SDMA than on ADMA. Both ADMA and SDMA were predictive of cardiovascular disease in multivariate analysis and the associated hazard ratios over the 5-year observation period were of similar strength: 3.86 (1.36-10.9) and 7.91 (1.94-32.3) for ADMA and SDMA, respectively (p=0.011 and 0.004). Separate analyses focused on quintile groups of SDMA revealed that the increase in cardiovascular risk was mainly confined to the top category (>0.80 micromol/L). CONCLUSION: This study argues against an exclusive ADMA effect in mediating cardiovascular risk. Instead, SDMA, its supposedly inactive counterpart, has similar diagnostic value in this large prospective cohort.
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Authors | Stefan Kiechl, Terry Lee, Peter Santer, Graham Thompson, Sotirios Tsimikas, Georg Egger, David W Holt, Johann Willeit, Qingbo Xu, Manuel Mayr |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 205
Issue 1
Pg. 261-5
(Jul 2009)
ISSN: 1879-1484 [Electronic] Ireland |
PMID | 19100547
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Nitric Oxide
- symmetric dimethylarginine
- N,N-dimethylarginine
- Arginine
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Topics |
- Adult
- Aged
- Arginine
(analogs & derivatives, metabolism)
- Cardiovascular Diseases
(blood, diagnosis)
- Cohort Studies
- Female
- Humans
- Male
- Mass Spectrometry
(methods)
- Middle Aged
- Nitric Oxide
(metabolism)
- Proportional Hazards Models
- Prospective Studies
- Risk
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