Abstract | BACKGROUND: METHODS: RESULTS: We observed aspergillosis in 8 lung, 3 kidney, and 1 heart recipient, with overall mean age of 40.6 years. Seven cases of Aspergillus tracheobronchitis were diagnosed in lung transplant recipients, all of them in the first 6 months after transplantation. All patients responded to antifungal therapy and bronchoscopic debridement. We observed 5 cases of invasive pulmonary aspergillosis. Three patients survived in response to antifungal treatment. The two patients who died were treated with a combination of itraconazole and amphotericin B, whereas all cured patients had been treated with voriconazole alone or in combination with caspofungin. CONCLUSION: It seems that the prognosis of aspergillosis in solid organ recipients is improving with new treatment regimens, particularly if they are used in early stages of infection.
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Authors | M Marjani, P Tabarsi, K Najafizadeh, F Rashid Farokhi, B Sharifkashani, S Motahari, A Abbasi, M R Masjedi, D Mansouri |
Journal | Transplantation proceedings
(Transplant Proc)
Vol. 40
Issue 10
Pg. 3663-7
(Dec 2008)
ISSN: 0041-1345 [Print] United States |
PMID | 19100461
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Antifungal Agents
(therapeutic use)
- Debridement
(methods)
- Drug Therapy, Combination
- Female
- Heart Transplantation
(adverse effects)
- Humans
- Iran
- Kidney Transplantation
(adverse effects, mortality)
- Lung Neoplasms
(surgery)
- Male
- Middle Aged
- Postoperative Complications
(epidemiology, microbiology)
- Pulmonary Aspergillosis
(drug therapy, epidemiology, surgery)
- Retrospective Studies
- Survival Analysis
- Survivors
- Young Adult
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