Abstract | BACKGROUND: The aim of the present research was to study the possible interference of hemosiderin deposits with the histological detection of dextran-coated, iron-labeled, mesenchymal stem cells after intracoronary administration in a porcine model of myocardial infarction. MATERIALS AND METHODS: A myocardial infarction was induced in six animals that received intracoronary iron-labeled autologous mesenchymal stem cells (group 1; n = 2) or placebo (group 2; n = 4). Six control animals without myocardial infarction underwent direct intramyocardial injections of iron-labeled autologous mesenchymal stem cells (group 3; n = 2) or placebo (group 4; n = 4). Histological sections from explanted hearts were stained with Prussian blue to identify dextran-coated, iron-labeled, mesenchymal stem cells. RESULTS: CONCLUSIONS:
|
Authors | M Rigol, N Solanes, M Roqué, J Farré, M Batlle, S Roura, N Bellera, C Prat-Vidal, A Sionis, J Ramírez, M Sitges, G Sanz, A Bayés-Genís, M Heras |
Journal | Transplantation proceedings
(Transplant Proc)
Vol. 40
Issue 10
Pg. 3619-22
(Dec 2008)
ISSN: 0041-1345 [Print] United States |
PMID | 19100453
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Ferric Compounds
- ferric oxide
- Hemosiderin
|
Topics |
- Animals
- Cell Separation
(methods)
- Disease Models, Animal
- Ferric Compounds
(analysis)
- Hemosiderin
(analysis)
- Mesenchymal Stem Cells
(cytology)
- Myocardial Infarction
(pathology, surgery)
- Stem Cell Transplantation
(methods)
- Swine
- Transplantation, Autologous
|