Abstract | OBJECTIVE: METHODS: RESULTS: The positive rates of the autoantibodies against beta1-receptors (44.9%) and M(2)-receptor (37.5%) in patients with type 2 diabetes with refractory hypertension were significantly higher than those in patients with type 2 diabetes without refractory hypertension (27.9% and 24.3%, respectively, all P < 0.05), in patients with hypertension without renal failure (11.7% and 15.0%, all P < 0.01) and in healthy controls (8.3% and 7.5%, all P < 0.01). In type 2 diabetes patients with refractory hypertension and renal failure (UAER > or = 200 microg/min), the positive rates of the autoantibodies against beta(1)-receptor (87.1%, 27/31) and against M(2)-receptor (67.7%, 21/31) were significantly higher than those in type 2 diabetes patients with refractory hypertension but without renal failure (UAER 20 - 199 microg /min, 46.7%, 28/60 and 41.7%, 25/60, respectively, all P < 0.05). CONCLUSION:
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Authors | Lin-shuang Zhao, Yu-hua Liao, Guang-da Xiang, Min Wang, Ling LE, Zi-hua Zhou, Xuan Lin, Hui-ling Sun |
Journal | Zhonghua xin xue guan bing za zhi
(Zhonghua Xin Xue Guan Bing Za Zhi)
Vol. 36
Issue 6
Pg. 527-30
(Jun 2008)
ISSN: 0253-3758 [Print] China |
PMID | 19100067
(Publication Type: Controlled Clinical Trial, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- Receptor, Muscarinic M2
- Receptors, Adrenergic, beta-1
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Topics |
- Aged
- Albuminuria
(etiology)
- Autoantibodies
(analysis)
- Diabetes Mellitus, Type 2
(complications, immunology)
- Female
- Humans
- Hypertension
(complications, immunology)
- Male
- Middle Aged
- Receptor, Muscarinic M2
(immunology)
- Receptors, Adrenergic, beta-1
(immunology)
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