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[The relation between positive rate of autoantibodies against beta1 and M2-adrenergic receptors and urinary albumin excretion rate in the type 2 diabetes mellitus with refractory hypertension].

AbstractOBJECTIVE:
To explore the relation between the positive rates of autoantibodies against beta(1) adrenergic receptor (beta1-receptor)and (M2-receptor) with urinary albumin excretion rate (UAER) in type 2 diabetes patients with refractory hypertension.
METHODS:
Autoantibodies against beta(1)- and M(2)-receptor as well as autoantibodies were determined in type 2 diabetes patients with (n = 136) or without (n = 111) refractory hypertension, hypertensive patients without renal failure (n = 60) and healthy control subjects (n = 40, control) by ELISA.
RESULTS:
The positive rates of the autoantibodies against beta1-receptors (44.9%) and M(2)-receptor (37.5%) in patients with type 2 diabetes with refractory hypertension were significantly higher than those in patients with type 2 diabetes without refractory hypertension (27.9% and 24.3%, respectively, all P < 0.05), in patients with hypertension without renal failure (11.7% and 15.0%, all P < 0.01) and in healthy controls (8.3% and 7.5%, all P < 0.01). In type 2 diabetes patients with refractory hypertension and renal failure (UAER > or = 200 microg/min), the positive rates of the autoantibodies against beta(1)-receptor (87.1%, 27/31) and against M(2)-receptor (67.7%, 21/31) were significantly higher than those in type 2 diabetes patients with refractory hypertension but without renal failure (UAER 20 - 199 microg /min, 46.7%, 28/60 and 41.7%, 25/60, respectively, all P < 0.05).
CONCLUSION:
The serum beta(1)- and M (2)-receptor autoantibodies are positively associated with the UAER level and suggest that these autoantibodies against beta(1) and M(2)-receptor may play important roles in the pathogenesis of the type 2 diabetes with refractory hypertension.
AuthorsLin-shuang Zhao, Yu-hua Liao, Guang-da Xiang, Min Wang, Ling LE, Zi-hua Zhou, Xuan Lin, Hui-ling Sun
JournalZhonghua xin xue guan bing za zhi (Zhonghua Xin Xue Guan Bing Za Zhi) Vol. 36 Issue 6 Pg. 527-30 (Jun 2008) ISSN: 0253-3758 [Print] China
PMID19100067 (Publication Type: Controlled Clinical Trial, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Autoantibodies
  • Receptor, Muscarinic M2
  • Receptors, Adrenergic, beta-1
Topics
  • Aged
  • Albuminuria (etiology)
  • Autoantibodies (analysis)
  • Diabetes Mellitus, Type 2 (complications, immunology)
  • Female
  • Humans
  • Hypertension (complications, immunology)
  • Male
  • Middle Aged
  • Receptor, Muscarinic M2 (immunology)
  • Receptors, Adrenergic, beta-1 (immunology)

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