A randomized clinical trial of oral steroids for ulnar neuropathy in type 1 and type 2 leprosy reactions.

Abstract

BACKGROUND:

Steroids regimens in leprosy neuropathies are still controversial in botth types of reactions.

METHOD:

For this trial, 21 patients with ulnar neuropathy were selected from 163 leprosy patients, 12 with type 1 reaction (T1R) and nine with type 2 (T2R). One experimental group started with prednisone 2 mg/kg/day and the control group with 1 mg/kg/day. A clinical score based on tests for spontaneous pain, nerve palpation, sensory and muscle function was used. Neurophysiological evaluation consisted on the motor nerve conduction of the ulnar nerve in three segments. Student "t" test for statistical analysis was applied on the results: before treatment, first week, first month and sixth month, between each regimen and types of reaction.

CONCLUSION:

In both reactions during the first month higher doses of steroids produced better results but, earlier treatment with lower dose was as effective. Short periods of steroid, 1 mg/Kg/day at the beginning and,tapering to 0,5 mg/Kg/day or less in one month turned out to be efficient in T2R.

• Authors: José Antonio Garbino, Marcos da Cunha Lopes Virmond, Somei Ura, Manoel Henrique Salgado, Bernard Naafs
• Journal: Arquivos de neuro-psiquiatria (Arq Neuropsiquiatr) Vol. 66 Issue 4 Pg. 861-7 (Dec 2008) ISSN: 1678-4227 [Electronic] Germany
• PMID: 19099126 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents
• Prednisone

Topics

• Adult
• Anti-Inflammatory Agents (administration & dosage)
• Female
• Humans
• Leprosy (complications, drug therapy, physiopathology)
• Male
• Middle Aged
• Neural Conduction (physiology)
• Pain Measurement
• Prednisone (administration & dosage)
• Reaction Time
• Treatment Outcome
• Ulnar Nerve (drug effects)
• Ulnar Neuropathies (drug therapy, etiology, physiopathology)
• Young Adult