Photodynamic therapy with aluminum-chloro-phthalocyanine induces necrosis and vascular damage in mice tongue tumors.

Abstract

In this paper we describe the efficacy of the liposomal-AlClPc (aluminum-chloro-phthalocyanine) formulation in PDT study against Ehrlich tumor cells proliferation in immunocompetent swiss mice tongue. Experiments were conduced in sixteen tumor induced mice that were divided in three control groups: (1) tumor without treatment; (2) tumor with 100J/cm(2) laser (670nm) irradiation; and (3) tumor with AlClPc peritumoral injection; and a PDT experimental group when tumors received AlClPc injection followed by tumor irradiation. Control groups present similar macroscopically and histological patterns after treatments, while PDT treatment induced 90% of Ehrlich tumor necrosis after 24h of one single application, showing the efficacy of liposome-AlClPc (aluminum-chloro-phthalocyanine) mediated PDT on the treatment of oral cancer.

• Authors: João Paulo Figueiró Longo, Silene Paulino Lozzi, Andreza Ribeiro Simioni, Paulo César Morais, Antônio Cláudio Tedesco, Ricardo Bentes Azevedo
• Journal: Journal of photochemistry and photobiology. B, Biology (J Photochem Photobiol B) Vol. 94 Issue 2 Pg. 143-6 (Feb 09 2009) ISSN: 1011-1344 [Print] Switzerland
• PMID: 19097802 (Publication Type: Journal Article)

Chemical References

• Indoles
• Organometallic Compounds
• chloroaluminum phthalocyanine

Topics

• Animals
• Indoles (administration & dosage, adverse effects, therapeutic use)
• Light
• Mice
• Necrosis (chemically induced)
• Organometallic Compounds (administration & dosage, adverse effects, therapeutic use)
• Photochemotherapy
• Temperature
• Tongue (blood supply, drug effects, pathology, radiation effects)
• Tongue Neoplasms (blood supply, drug therapy, pathology)