Abstract |
RNA viruses are a major source of respiratory diseases worldwide. The lack of effective therapeutical treatment underlines the importance of research for new antiviral compounds. Raoulic acid is a principal ingredient of the plant Raoulia australis Hook. F. Antiviral assay using cytopathic effect (CPE) reduction method showed that raoulic acid possessed strong antiviral activity against human rhinovirus 2 (HRV2) with a 50% inhibition concentration (IC(50)) value of less than 0.1mug/ml, human rhinovirus 3 (HRV3) with a IC(50) value of 0.19 microg/ml, coxsackie B3 (CB3) virus with IC(50) values of 0.33 microg/ml, coxsackie B4 (CB4) virus with IC(50) values of 0.40 microg/ml, and enterovirus 71 (EV71) virus with IC(50) values of less than 0.1 microg/ml. However, the compound did not possess antiviral activity against influenza A (Flu A/PR, Flu A/WS, H1N1) and B viruses at four concentrations ranging from 0.1 to 100 microg/ml.
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Authors | H J Choi, C H Lim, J H Song, S H Baek, D H Kwon |
Journal | Phytomedicine : international journal of phytotherapy and phytopharmacology
(Phytomedicine)
Vol. 16
Issue 1
Pg. 35-9
(Jan 2009)
ISSN: 1618-095X [Electronic] Germany |
PMID | 19097770
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiviral Agents
- Terpenes
- raoulic acid
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Topics |
- Antiviral Agents
(chemistry, isolation & purification, pharmacology)
- Asteraceae
- HeLa Cells
- Humans
- Phytotherapy
- RNA Viruses
(drug effects)
- Terpenes
(chemistry, isolation & purification, pharmacology)
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