Clinical significance of Gata-1, Gata-2, EKLF, and c-MPL expression in acute myeloid leukemia.

Abstract	The aim of this study was to evaluate the biological correlation and prognostic impact of Gata-1, Gata-2, EKLF, and c-MPL transcript level in a group of 41 acute myeloid leukemia (AML) patients. Gata-1 overexpression was related to advanced age and a low percentage of bone marrow blasts and was associated with the expression of CD34 antigen and lymphoid T markers. The negative impact of Gata-1 expression on the probability of achieving complete remission has been confirmed. Gata-2 overexpression was associated with a low percentage of blasts in BM and males. Expression of c-MPL was associated with CD34+ AML and M2 FAB AML subtype. A higher expression of EKLF was found in secondary AML versus primary AML. Nevertheless, patients expressing EKLF had a longer overall survival and event free survival than those patients that did not express EKLF. Our study has identified expression of EKLF as a factor with a favorable impact on prognosis in AML.
Authors	Rosa M Ayala, Joaquín Martínez-López, Enriqueta Albízua, Amalia Diez, Florinda Gilsanz
Journal	American journal of hematology (Am J Hematol) Vol. 84 Issue 2 Pg. 79-86 (Feb 2009) ISSN: 1096-8652 [Electronic] United States
PMID	19097174 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	GATA1 Transcription Factor GATA1 protein, human GATA2 Transcription Factor GATA2 protein, human Kruppel-Like Transcription Factors Neoplasm Proteins Receptors, Thrombopoietin erythroid Kruppel-like factor MPL protein, human
Topics	Adolescent Adult Aged Bone Marrow (pathology) Chromosome Aberrations Disease-Free Survival Erythropoiesis (genetics) GATA1 Transcription Factor (analysis, physiology) GATA2 Transcription Factor (analysis, physiology) Gene Expression Regulation, Neoplastic Humans Kruppel-Like Transcription Factors (analysis, physiology) Leukemia, Myeloid, Acute (genetics, metabolism, mortality, pathology) Middle Aged Neoplasm Proteins (analysis, physiology) Neoplasms, Second Primary (genetics, metabolism, mortality, pathology) Prognosis Receptors, Thrombopoietin (analysis, physiology) Survival Analysis Young Adult

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