[Clinical outcomes of lamivudine therapy and HLA alleles in chronic hepatitis B patients].

Abstract

BACKGROUND/AIMS:

The human leukocyte antigen (HLA) system is an integral component of immune response. Highly polymorphic HLA genes may play a pivotal role in the response of antiviral therapy. We investigated the effects of HLA gene polymorphism on the clinical outcome of chronic hepatitis B patients who received lamivudine treatment.

METHODS:

Depending on their clinical response to lamivudine therapy, a total of sixty one patients were divided into following groups; non-responders, viral breakthroughers, relapsers, and seroconverters. HLA-A, -B, -Cw, -DRB and HLA-DRB1 alleles typing was performed on each group through the polymerase chain reaction and the sequence-specific oligonucleotide hybridization method. The distribution patterns of HLA-A, HLA-B, HLA-Cw, HLA-DRB, and HLA-DRB1 were then analysed.

RESULTS:

When non-responders were compared to the other groups, high frequencies in HLA-Cw1, HLA-DRB14 and HLA-DRB4 (p=0.015, 0.033 and 0.004 respectively) were evident. When seroconverters were compared to viral breakthroughers, high frequencies in HLA-A2 and HLA-DRB4 (p=0.048, 0.025 respectively) were evident.

CONCLUSIONS:

Our data suggests that HLA-A2, HLA-Cw1, HLA-DRB14 genes are related to the clinical outcomes of lamivudine treatment in chronic hepatitis B patients. These genes may be used in the prediction of the clinical outcome of lamivudine therapy in chronic hepatitis B patients.

• Authors: Ji Min Oh, Kyu Heum Kwon, Jang Eon Kim, Jin Ho Choi, Sun Hee Beom, Sang Hyuk Lee, Yong Jik Lee, Mi Young Park, Mee Kyung Jung, Kye Heui Lee
• Journal: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi (Korean J Gastroenterol) Vol. 52 Issue 6 Pg. 368-75 (Dec 2008) ISSN: 1598-9992 [Print] Korea (South)
• PMID: 19096254 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antiviral Agents
• HLA Antigens
• Lamivudine

Topics

• Adult
• Alleles
• Antiviral Agents (administration & dosage)
• Drug Resistance, Viral
• Female
• Genetic Predisposition to Disease
• HLA Antigens (genetics)
• Hepatitis B virus (drug effects)
• Hepatitis B, Chronic (drug therapy)
• Humans
• Lamivudine (administration & dosage)
• Male
• Middle Aged
• Polymorphism, Genetic
• Treatment Outcome