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Genetic correlates of protection against HIV infection: the ally within.

Abstract
Repeated exposure to HIV does not necessarily result in infection and HIV infection does not inevitably lead to the development of the AIDS. Multiple immunological and genetic features can confer resistance to HIV acquisition and progression at different steps in viral infection; a full understanding of these mechanisms could result in the development of novel therapeutic and vaccine approaches for HIV infection. In this review, we focus on the genetic mechanisms associated with resistance to HIV infection and to the progression to AIDS.
AuthorsL Piacentini, M Biasin, C Fenizia, M Clerici
JournalJournal of internal medicine (J Intern Med) Vol. 265 Issue 1 Pg. 110-24 (Jan 2009) ISSN: 1365-2796 [Electronic] England
PMID19093964 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Cytokines
  • HLA Antigens
  • Receptors, CCR5
Topics
  • Alleles
  • Cytokines (genetics)
  • Disease Progression
  • Genetic Predisposition to Disease
  • HIV Infections (immunology)
  • HIV Long-Term Survivors
  • HIV Seronegativity (immunology)
  • HIV-1 (immunology)
  • HLA Antigens (genetics)
  • Humans
  • Promoter Regions, Genetic
  • Receptors, CCR5 (genetics)

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