Arterial infusion chemotherapy in patient with repeated recurrent tumor of cecal cancer: report of a case.

Abstract

PURPOSE:

We report a patient with a repeated recurrent tumor after Right-hemicolectomy for advanced cecal cancer who was treated by intra-arterial infusions of 5-fluorouracil (5-FU).

METHODS:

A computed tomography scan revealed a pelvic mass involving the psoas major muscle and quadratos lumborum muscle, in contact with the widely projecting toward L2-S2. The fluorodeoxyglucose-positron emission tomography (FDG-PET) revealed an accumulation spot in the same place. This case was deemed in operable, and one-shot bolus of 5-FU was administered through the tumor feeding arteries: the left 3rd, 4th lumbar, and ilio -- lumbar arteries at a dosage of 250 mg/body from each artery.

RESULTS:

A partial regression of the tumor was observed by computed tomography. The serum level of carbohydrate antigen 19-9 returned normal in 8 months. During chemotherapy, the side effect and complications were tolerable, and she experienced only grade-1 nausea caused by 5-fluorouracil.

CONCLUSION:

A long-time, intra-arterial 5-fluorouracil infusion could control effectively and safely.

• Authors: Masaichi Ogawa, Yoshihiko Takao, Michiaki Watanabe, Ken Eto, Tetsuya Yamagata, Takurou Ushigome, Sadao Anazawa, Katsuhiko Yanaga
• Journal: Cancer investigation (Cancer Invest) Vol. 26 Issue 10 Pg. 999-1001 (Dec 2008) ISSN: 1532-4192 [Electronic] England
• PMID: 19093258 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Radiopharmaceuticals
• Fluorodeoxyglucose F18
• Fluorouracil

Topics

• Antimetabolites, Antineoplastic (administration & dosage, therapeutic use)
• Cecal Neoplasms (diagnostic imaging, drug therapy, surgery)
• Female
• Fluorodeoxyglucose F18
• Fluorouracil (administration & dosage, therapeutic use)
• Humans
• Infusions, Intra-Arterial
• Middle Aged
• Neoplasm Recurrence, Local
• Radiopharmaceuticals
• Tomography, X-Ray Computed
• Treatment Outcome