Protection against Asiatic Taenia solium induced by a recombinant 45W-4B protein.

Abstract

Taenia solium is a great threat not only to human health but also to the pig-raising industry. Oncospheral stage-specific 45W proteins are good candidates for the development of anticysticercosis vaccines. In this study, a recombinant 45W-4B protein was highly produced and used for vaccination. Two animal trials resulted in a significant reduction in parasite burden induced by the definite protein against Asiatic T. solium, up to 97.0% and 98.4%, respectively. These provide informative results for the development of effective 45W-4B vaccines against cysticercosis caused by both Chinese and Mexican T. solium isolates and even by other isolates.

• Authors: Xuenong Luo, Yadong Zheng, Junling Hou, Shaohua Zhang, Xuepeng Cai
• Journal: Clinical and vaccine immunology : CVI (Clin Vaccine Immunol) Vol. 16 Issue 2 Pg. 230-2 (Feb 2009) ISSN: 1556-679X [Electronic] United States
• PMID: 19091992 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Helminth

Topics

• Animals
• Antigens, Helminth (immunology)
• China
• Cysticercosis (prevention & control, veterinary)
• Swine
• Swine Diseases (immunology, prevention & control)
• Taenia solium (immunology)