A rare case of massive retroperitoneal hemorrhage after bone marrow aspiration alone.

Abstract

The use of dapsone is increasing even though overdose is rarely reported and physicians must be aware of its toxicity and management. Mortality can occur due to methemoglobinemia and hemolytic anemia. Although activated charcoal and methylene blue are recommended, the use of hemodialysis is reported only in few studies. Literature on the kinetic profile indicates that 50% to 80% of dapsone is protein bound and indicates a possibility to dialyze the unbound form. This study describes a case of deliberate severe dapsone overdose with cyanosis, methemoglobinemia, and hemolytic anemia, which improved after repetitive hemodialysis.

• Authors: Hsien-Lung Tsai, Shih-Wei Liu, Chorng-Kuang How, Chii-Hwa Chern, David Hung-Tsang Yen, Chun-I Huang
• Journal: The American journal of emergency medicine (Am J Emerg Med) Vol. 26 Issue 9 Pg. 1070.e5-6 (Nov 2008) ISSN: 1532-8171 [Electronic] United States
• PMID: 19091292 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Bone Marrow Examination (adverse effects)
• Female
• Hemorrhage (etiology)
• Humans
• Retroperitoneal Space