[The experimental and clinical antitumor action of the interferon inducer larifan].

Abstract

The paper presents the results of experimental and clinical studies on the antitumor effect of larifan. A statistically significant inhibition of growth of some continuous mouse tumors by larifan in a dose of 2.5 mg/kg given for 5-6 days and by a combination of larifan with an immunomodulator, inosiplex, tested on hepatoma XXIIa which has a rather low sensitivity to larifan. The antitumor effect of larifan may be due to interferon production and immunomodulating effect. Treatment with 0.05% larifan ointment of patients with cervical dysplasia of moderate degree resulted in a significant increase of previously diminished production of alpha-interferon after 10-14 vaginal tampons and clinical cure in 88% of cases. A course of 8-10-day larifan monotherapy given before radial therapy resulted in a considerable improvement in patients with cervical cancer of II-III stages, and subsequently, for 1 1/2-month combined radial therapy, no significant changes in production of alpha-IF were observed. At the same time, in patients with cervical cancer treated by radial therapy alone a significant decrease of alpha-IF production by blood mononuclears was observed by the end of therapy.

• Authors: M G Gasparian, N G Dzhagatspanian, R A Gevorkian, L A Kamalian
• Journal: Voprosy virusologii (Vopr Virusol) 1991 Mar-Apr Vol. 36 Issue 2 Pg. 127-30 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Protivoopukholevoe deĭstvie induktora interferona larifana v éksperimente i klinike.
• PMID: 1909072 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Interferon Inducers
• Organic Chemicals
• larifan
• Interferon-gamma

Topics

• Administration, Intravaginal
• Animals
• Antineoplastic Agents (administration & dosage, therapeutic use)
• Combined Modality Therapy
• Drug Evaluation
• Drug Screening Assays, Antitumor
• Female
• Interferon Inducers (administration & dosage, therapeutic use)
• Interferon-gamma (blood)
• Mice
• Mice, Inbred Strains
• Neoplasm Transplantation
• Neoplasms, Experimental (drug therapy, immunology)
• Organic Chemicals
• Uterine Cervical Dysplasia (drug therapy, immunology)
• Uterine Cervical Neoplasms (drug therapy, immunology)