Association of the dystrobrevin binding protein 1 gene (DTNBP1) in a bipolar case-control study (BACCS).

Abstract

Recent studies suggest a degree of overlap in genetic susceptibility across the traditional categories of schizophrenia and bipolar disorder. There is some evidence for an association of the dystrobrevin binding protein 1 gene (DTNBP1) with schizophrenia, and, thus, this gene has also become a focus of further investigation in bipolar disorder (BD). The aim of our study is to explore the association of DTNBP1 with BD and with a sub phenotype, presence/absence of psychotic symptoms, in a sample of 515 patients with BD (ICD10/DSMIV) and 1,316 ethnically matched control subjects recruited from the UK. Seven DTNBP1 SNPs: rs2743852 (SNP C), rs760761 (P1320), rs1011313 (P1325), rs3213207 (P1635), rs2619539 (P1655), rs16876571 and rs17470454 were investigated using the SNPlex genotyping system and 1 SNP (rs2619522) genotypes were imputed. Association analyses were conducted in a sample of 452 cases and 956 controls. We found significant differences in genotypic and allelic frequencies of rs3213207 and rs760761 of DTNBP1 between bipolar patients and controls. We also showed a global haplotypic association and an association of a particular haplotype with BD. Our results are consistent with previous studies in term of a general association between DTNBP1 and bipolar disorder and provide additional evidence that a portion of the genotypic overlap between schizophrenia and bipolar affective disorder is attributable to this gene.

• Authors: Darya Gaysina, Sarah Cohen-Woods, Philip C Chow, Livia Martucci, Alexandra Schosser, Harriet A Ball, Federica Tozzi, Julia Perry, Pierandrea Muglia, Ian W Craig, Peter McGuffin, Anne Farmer
• Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics (Am J Med Genet B Neuropsychiatr Genet) Vol. 150B Issue 6 Pg. 836-44 (Sep 05 2009) ISSN: 1552-485X [Electronic] United States
• PMID: 19089808 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: (c) 2008 Wiley-Liss, Inc.

Chemical References

• Carrier Proteins
• DTNBP1 protein, human
• Dysbindin
• Dystrophin-Associated Proteins

Topics

• Adult
• Alleles
• Bipolar Disorder (genetics)
• Carrier Proteins (genetics)
• Case-Control Studies
• Dysbindin
• Dystrophin-Associated Proteins
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Haplotypes
• Humans
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Schizophrenia (genetics)