JBIR-23 and -24, novel anticancer agents from Streptomyces sp. AK-AB27.

Abstract

The screening for active compounds against malignant pleural mesothelioma (MPM) cells produced by Streptomyces sp. AK-AB27 resulted in the isolation of two compounds with a dodecahydrodibenzo[b,d]furan skeleton named JBIR-23 (1) and -24 (2). Their structures were established on the basis of extensive NMR and MS analyses. Compounds 1 and 2 exhibited cytotoxic effects against several MPM cell lines.

• Authors: Keiichiro Motohashi, Ji-Hwan Hwang, Yoshitaka Sekido, Motoki Takagi, Kazuo Shin-ya
• Journal: Organic letters (Org Lett) Vol. 11 Issue 2 Pg. 285-8 (Jan 15 2009) ISSN: 1523-7052 [Electronic] United States
• PMID: 19086885 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Benzofurans
• JBIR-23
• JBIR-24

Topics

• Antineoplastic Agents (chemistry, isolation & purification, pharmacology, therapeutic use)
• Benzofurans (chemistry, isolation & purification, pharmacology, therapeutic use)
• Cell Line, Tumor
• Drug Evaluation, Preclinical
• Humans
• Mesothelioma (drug therapy)
• Streptomyces (chemistry, classification)