HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Glutathione-S-transferase pi (GSTP1) codon 105 polymorphism is not associated with oxaliplatin efficacy or toxicity in advanced colorectal cancer patients.

AbstractPURPOSE:
Oxaliplatin is detoxified by conjugation to glutathione via the enzyme Glutathione-S-transferase pi (GSTP1). The aim of this study is to investigate the association of GSTP1 Ile105Val genetic polymorphism with oxaliplatin efficacy and toxicity in advanced colorectal cancer (ACC) patients.
EXPERIMENTAL DESIGN:
A total of 91 ACC patients received capecitabine and oxaliplatin (CAPOX) as a part of a multicentre phase-III study of the Dutch Colorectal Cancer Group. Tumour response was evaluated according to RECIST, toxicity was graded using CTC, and GSTP1 Ile105Val was determined by pyrosequencing.
RESULTS:
Overall survival after CAPOX was similar for patients with the Ile/Ile (11.5 mo), Ile/Val (11.6 mo) and Val/Val (12.6 mo) genotypes (p=0.602). Likewise, there were no statistically significant differences in progression-free survival (p=0.252). Overall grades 3-4 toxicity was not related to genotype (p=0.313). There were no differences in any grade or grades 3-4 neurotoxicity amongst the patients who received > or =500 mg/m(2) of oxaliplatin (p-values of 0.376 and 0.772, respectively).
CONCLUSIONS:
The results of this study indicate that the GSTP1 genotype is not predictive for progression-free survival or overall survival in ACC patients treated with CAPOX. Moreover, overall neurotoxicity and neurotoxicity in patients receiving 500 mg/m(2) of oxaliplatin was not associated with GSTP1 genotype.
AuthorsDina M Kweekel, Hans Gelderblom, Ninja F Antonini, Tahar Van der Straaten, Johan W R Nortier, Cornelis J A Punt, Henk-Jan Guchelaar
JournalEuropean journal of cancer (Oxford, England : 1990) (Eur J Cancer) Vol. 45 Issue 4 Pg. 572-8 (Mar 2009) ISSN: 1879-0852 [Electronic] England
PMID19084393 (Publication Type: Clinical Trial, Phase III, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Codon
  • Organoplatinum Compounds
  • Oxaliplatin
  • Deoxycytidine
  • Capecitabine
  • Glutathione S-Transferase pi
  • Fluorouracil
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
  • Capecitabine
  • Codon
  • Colorectal Neoplasms (drug therapy, genetics)
  • Deoxycytidine (administration & dosage, analogs & derivatives)
  • Epidemiologic Methods
  • Female
  • Fluorouracil (administration & dosage, analogs & derivatives)
  • Genetic Predisposition to Disease
  • Genotype
  • Glutathione S-Transferase pi (genetics)
  • Humans
  • Male
  • Middle Aged
  • Neurotoxicity Syndromes (etiology, genetics)
  • Organoplatinum Compounds (administration & dosage, adverse effects)
  • Oxaliplatin
  • Polymorphism, Genetic
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: