Chemopreventive efficacy of betel leaf extract and its constituents on 7,12-dimethylbenz(a)anthracene induced carcinogenesis and their effect on drug detoxification system in mouse skin.

Abstract

Effects of topically applied betel leaf extract (BLE) and its constituents. beta-carotene, alpha-tocopherol, eugenol and hydroxychavicol on 7,12-dimethylbenz(a)anthracene (DMBA) induced skin tumors were evaluated in two strains of mice. BLE, beta-carotene and alpha-tocopherol, significantly inhibited the tumor formation by 83, 86, 86% in Swiss mice and 92, 94 and 89% in male Swiss bare mice respectively. Hydroxychavicol showed 90% inhibition in Swiss bare mice at 24 weeks of treatment. Eugenol showed minimal protection in both strains of mice. The mean latency period and survivors in BLE, beta-carotene, alpha-tocopherol and hydroxychavicol treated groups were remarkably high as compared to DMBA alone treated group. Intraperitoneal injection of betal leaf constituents showed a significant effect on both glutathione and glutathione S-transferase levels in the Swiss mouse skin.

• Authors: M A Azuine, A J Amonkar, S V Bhide
• Journal: Indian journal of experimental biology (Indian J Exp Biol) Vol. 29 Issue 4 Pg. 346-51 (Apr 1991) ISSN: 0019-5189 [Print] India
• PMID: 1908438 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• 9,10-Dimethyl-1,2-benzanthracene

Topics

• 9,10-Dimethyl-1,2-benzanthracene
• Animals
• Antineoplastic Agents, Phytogenic
• Areca (analysis)
• Female
• Inactivation, Metabolic
• Male
• Mice
• Plants, Medicinal
• Skin Neoplasms (chemically induced, prevention & control)