HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[An injury of the liver caused by ischemia-reperfusion in rat liver].

Abstract
Cellular damage of various organs by ischemia following reperfusion is assumed to be at least in part due to lipid peroxidation in biomembranes, and oxygen-derived free radicals play a major role. The level of lipid peroxides in liver tissue increased during 90-min ischemia. When reflow of hepatic blood was allowed, a greater increase in the lipid peroxides was observed. Similar increases were obtained in several serum markers (GOT, GPT and LDH) during the period of ischemia or ischemia-reperfusion. In addition, levels of cytochrome p-450 and NADPH cyt. c reductase activity decreased in proportion to the decrease in microsomal proteins during ischemia or ischemia-reperfusion. On the other hand, superoxide dismutase in blood was significantly increased by ischemia-reperfusion. Rats died within 2 days after liver ischemia of 90 min, while all animals subjected to 30-min ischemia survived. Histopathological examinations indicated that extensive coagulation with erythrocytes occurred and the extent was dependent on the time of ischemia. The liver injury by ischemia-reperfusion could be a useful experimental model for studying liver injury induced by free radicals, for developing hepatoprotective drugs, or for investigating liver transplantation.
AuthorsT Egashira, T Nagai, Y Kimba, F Murayama, S Goto, Y Kudo, S Sudo, T Kono, Y Yamanaka
JournalNihon yakurigaku zasshi. Folia pharmacologica Japonica (Nihon Yakurigaku Zasshi) Vol. 97 Issue 6 Pg. 339-50 (Jun 1991) ISSN: 0015-5691 [Print] Japan
PMID1908428 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Free Radicals
  • Lipid Peroxides
  • Cytochrome P-450 Enzyme System
  • L-Lactate Dehydrogenase
  • Superoxide Dismutase
  • NADPH-Ferrihemoprotein Reductase
  • Aspartate Aminotransferases
  • Alanine Transaminase
Topics
  • Alanine Transaminase (metabolism)
  • Animals
  • Aspartate Aminotransferases (metabolism)
  • Cytochrome P-450 Enzyme System (metabolism)
  • Disease Models, Animal
  • Free Radicals
  • L-Lactate Dehydrogenase (metabolism)
  • Lipid Peroxidation
  • Lipid Peroxides (metabolism)
  • Liver Diseases (metabolism, pathology)
  • Male
  • NADPH-Ferrihemoprotein Reductase (metabolism)
  • Rats
  • Rats, Inbred Strains
  • Reperfusion Injury (metabolism, pathology)
  • Superoxide Dismutase (blood)
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: