Abstract | INTRODUCTION: Antimonial compounds are regarded as the treatment of choice for cutaneous leishmaniasis (CL). Systemic administration of these drugs has some side effects including cardio toxicity and electrocardiogram (EKG) changes. The objective of our study was to evaluate EKG changes in the patients with CL treated with systemic glucantime. MATERIALS AND METHODS: One hundred and thirty-one patients were enrolled in this prospective study. All of the selected patients had confirmed CL and were candidates for treatment with systemic glucantime. The patients were treated with systemic glucantime and EKG was performed before, during (weekly) and 1 month after cessation of the treatment. All of the collected data were analysed using SPSS software. RESULTS: CONCLUSIONS: Our results showed that treatment with glucantime can induce many ECG changes as QT prolongation have significant risk. We suggest that ECG monitoring should be performed in high-risk patients undergoing glucantime treatment with special attention to ECG changes mostly prolonged QT interval.
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Authors | Giti Sadeghian, Hengameh Ziaei, Masumeh Sadeghi |
Journal | Annals of the Academy of Medicine, Singapore
(Ann Acad Med Singap)
Vol. 37
Issue 11
Pg. 916-8
(Nov 2008)
ISSN: 0304-4602 [Print] Singapore |
PMID | 19082196
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antiprotozoal Agents
- Organometallic Compounds
- Meglumine
- Meglumine Antimoniate
- Antimony
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Topics |
- Administration, Oral
- Adult
- Animals
- Antimony
- Antiprotozoal Agents
(administration & dosage, adverse effects)
- Atrial Premature Complexes
(chemically induced, physiopathology)
- Bradycardia
(chemically induced, physiopathology)
- Bundle-Branch Block
(chemically induced, physiopathology)
- Dose-Response Relationship, Drug
- Electrocardiography
(drug effects)
- Female
- Follow-Up Studies
- Humans
- Leishmaniasis, Cutaneous
(complications, drug therapy, physiopathology)
- Male
- Meglumine
(administration & dosage, adverse effects)
- Meglumine Antimoniate
- Organometallic Compounds
(administration & dosage, adverse effects)
- Prognosis
- Prospective Studies
- Ventricular Premature Complexes
(chemically induced, physiopathology)
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