Cucurbituril-based nanoparticles: a new efficient vehicle for targeted intracellular delivery of hydrophobic drugs.

Abstract

Cucurbituril-based nanoparticles (CB[6]NPs) serve as new efficient vehicles for delivery of hydrophobic drugs, which have unique features including (1) a high drug loading capacity and efficiency, (2) noncovalently tunable surfaces, (3) efficient delivery of hydrophobic drugs into a cancer cell by receptor-mediated endocytosis, and (4) facile release of drugs into cytoplasm, which enhances the pharmaceutical effects of the drugs.

• Authors: Kyeng Min Park, Kyungwon Suh, Hyuntae Jung, Don-Wook Lee, Youngjoo Ahn, Jeeyeon Kim, Kangkyun Baek, Kimoon Kim
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Issue 1 Pg. 71-3 (Jan 07 2009) ISSN: 1359-7345 [Print] England
• PMID: 19082002 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Coloring Agents
• Macrocyclic Compounds
• Oxazines
• Pharmaceutical Preparations
• Pharmaceutical Vehicles
• cucurbit(n)uril
• Water
• nile red

Topics

• Coloring Agents
• Cytoplasm (drug effects, metabolism)
• Drug Delivery Systems
• HeLa Cells
• Humans
• Macrocyclic Compounds (chemistry)
• Microscopy, Confocal
• Nanoparticles (chemistry)
• Oxazines
• Particle Size
• Pharmaceutical Preparations (chemistry)
• Pharmaceutical Vehicles (chemistry)
• Photochemistry
• Solubility
• Water