Aspernolides A and B, butenolides from a marine-derived fungus Aspergillus terreus.

Abstract

Two aromatic butenolides, aspernolides A and B along with the known metabolites, butyrolactone I, terrein and physcion were isolated from the fermentation broth of a soft coral derived fungus Aspergillus terreus. The structures of these metabolites were assigned on the basis of detailed spectroscopic analysis. The absolute stereochemistry of aspernolides A (1) and B (2) was established by their preparation from the known butyrolactone I. Biogenetically aspernolides A and B must be derived from butyrolactone I, a well known specific inhibitor of cyclin dependent kinase (cdk) from A. terreus. When tested, aspernolide A exhibited mild cytotoxicity against cancer cell lines.

• Authors: Rajesh R Parvatkar, Celina D'Souza, Ashootosh Tripathi, Chandrakant G Naik
• Journal: Phytochemistry (Phytochemistry) Vol. 70 Issue 1 Pg. 128-32 (Jan 2009) ISSN: 0031-9422 [Print] England
• PMID: 19081582 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• aspernolide A
• aspernolide B
• 4-Butyrolactone

Topics

• 4-Butyrolactone (analogs & derivatives, chemistry)
• Aspergillus (chemistry, metabolism)
• Molecular Biology