Apolipoprotein A-I mimetic peptides.
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| Abstract |
Recent publications reveal the mechanism of action of apolipoprotein A-I (apoA-I) mimetic peptides to be the remarkable binding affinity that oxidized lipids have for these peptides compared with apoA-I. There was no difference in the binding affinity of oxidized lipids or in peptide efficacy in reducing inflammation and atherosclerosis in rabbits injected with peptides synthesized from all D- or all L-amino acids. The apoA-I mimetic peptide 4F increased the formation of pre-beta high-density lipoprotein, increased cholesterol efflux, and reduced lipoprotein oxidation in vitro; it increased antioxidants and vascular repair in type 1 diabetic rats; it improved vasodilation, oxidative stress, myocardial inflammation, and angiogenic potential in a mouse model of scleroderma; it reduced renal inflammation in low-density lipoprotein receptor-null mice fed a Western diet; it reduced arthritis in a rat model; it reduced adiposity, increased adiponectin levels, and improved insulin sensitivity in obese mice; and it improved high-density lipoprotein inflammatory properties in humans with coronary heart disease.
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| Authors | Brian J Van Lenten, Alan C Wagner, G M Anantharamaiah, Mohamad Navab, Srinivasa T Reddy, Georgette M Buga, Alan M Fogelman |
| Journal | Current atherosclerosis reports (Curr Atheroscler Rep) Vol. 11 Issue 1 Pg. 52-7 (Jan 2009) ISSN: 1534-6242 [Electronic] United States |
| PMID | 19080728 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review) |
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