[Treatment of great hematoma in brain hemorrhage with multi-point puncture and continuous irrigation-draining]

• Abstract: OBJECTIVE: To investigate the clinical effect of multi-point aspiration combined with continuous irrigation with urokinase in treating great hematoma as the result of brain hemorrhage due to hypertension. METHODS: Ninety-four patients with great hematoma as the result of brain hemorrhage due to hypertension, aged 70, were randomly divided into 2 equal groups: one point puncture group and multi-point puncture group. Both groups underwent puncture under local or general anesthesia and were irrigated with urokinase continually. The outcomes were recorded and analyzed. RESULTS: The case-fatality rate of the multi-point puncture group was 10.87, significantly lower than that of the one-point puncture group (20.83, P < 0.05). The superiority rate of recovery of the multi-point group was 78.26%, significantly higher than that of the one-point puncture group (64.58%, P < 0.05). In 15 days, the resolution rate of brain hematoma of the multi-point group was 67.43%, significantly higher than that of the one point puncture group (23.68%, P < 0.01). The re-hemorrhage rate of the multi-point puncture group was 8.95%, significantly lower than that of the one-point puncture group (12.5%, P < 0.05). CONCLUSION: Multi-point puncture and continuous irrigation decrease the intracranial pressure quickly and suck the hematoma more effectively, especially for the great and irregular hematoma of brain. Continuous urokinase irrigation-drainage is able to keep the concentration of urokinase at an effective level, thus continuously washing, liquefying, draining, and resolving the brain hematoma.
• Authors: Xiao-ming Huang, Shi-ping Chen, Wen Cheng, Xiao-dong Yuan, Wen-hua Tang (Affiliation: Department of Neurosurgery, Chengdu Railroad Central Hospital, Chengdu 610081, China.)
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 88 Issue 39 Pg. 2786-8 (Oct 28 2008) ISSN: 0376-2491 [Print] China
• PMID: 19080457 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Fibrinolytic Agents
• Urokinase-Type Plasminogen Activator

Topics

• Aged
• Aged, 80 and over
• Female
• Fibrinolytic Agents (administration & dosage)
• Hematoma (therapy)
• Humans
• Intracranial Hemorrhage, Hypertensive (therapy)
• Irrigation (methods)
• Male
• Middle Aged
• Paracentesis
• Urokinase-Type Plasminogen Activator (administration & dosage)