The PRMT1 gene expression pattern in colon cancer.

Abstract

The methylation of arginine has been implicated in many cellular processes, such as regulation of transcription, mRNA splicing, RNA metabolism and transport. The enzymes responsible for this modification are the protein arginine methyltransferases. The most abundant methyltransferase in human cells is protein arginine methyltransferase 1. Methylation processes appear to interfere in the emergence of several diseases, including cancer. During our study, we examined the expression pattern of protein arginine methyltransferase 1 gene in colon cancer patients. The emerging results showed that the expression of one of the gene variants is associated with statistical significant probability to clinical and histological parameters, such as nodal status and stage. This is a first attempt to acquire an insight on the possible relation of the expression pattern of protein arginine methyltransferase 1 and colon cancer progression.

• Authors: K Mathioudaki, A Papadokostopoulou, A Scorilas, D Xynopoulos, N Agnanti, M Talieri
• Journal: British journal of cancer (Br J Cancer) Vol. 99 Issue 12 Pg. 2094-9 (Dec 16 2008) ISSN: 1532-1827 [Electronic] England
• PMID: 19078953 (Publication Type: Journal Article)

Chemical References

• DNA, Complementary
• Repressor Proteins
• PRMT1 protein, human
• Protein-Arginine N-Methyltransferases

Topics

• Adult
• Aged
• Aged, 80 and over
• Biopsy
• Colonic Neoplasms (enzymology, genetics, pathology, surgery)
• DNA, Complementary (genetics)
• Disease Progression
• Gene Expression Regulation, Neoplastic (genetics)
• Humans
• Middle Aged
• Prognosis
• Protein-Arginine N-Methyltransferases (genetics, metabolism)
• Repressor Proteins (genetics, metabolism)