Abstract | BACKGROUND: Members of the genus Rhodococcus are frequently found in soil and other natural environments and are highly resistant to stresses common in those environments. The accumulation of storage compounds permits cells to survive and metabolically adapt during fluctuating environmental conditions. The purpose of this study was to perform a genome-wide bioinformatic analysis of key genes encoding metabolism of diverse storage compounds by Rhodococcus jostii RHA1 and to examine its ability to synthesize and accumulate triacylglycerols (TAG), wax esters, polyhydroxyalkanoates (PHA), glycogen and polyphosphate ( PolyP). RESULTS: CONCLUSION: RHA1 possess key genes to accumulate diverse storage compounds. Under nitrogen-limiting conditions lipids are the principal storage compounds. An extensive capacity to synthesize and metabolize storage compounds appears to contribute versatility to RHA1 in its responses to environmental stresses.
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Authors | Martín A Hernández, William W Mohn, Eliana Martínez, Enrique Rost, Adrián F Alvarez, Héctor M Alvarez |
Journal | BMC genomics
(BMC Genomics)
Vol. 9
Pg. 600
(Dec 12 2008)
ISSN: 1471-2164 [Electronic] England |
PMID | 19077282
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bacterial Proteins
- Lipids
- Polyhydroxyalkanoates
- Polyphosphates
- Triglycerides
- Waxes
- Glycogen
- Acyltransferases
- Diacylglycerol O-Acyltransferase
- long-chain-alcohol O-fatty-acyltransferase
- Esterases
- Lipase
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Topics |
- Acyltransferases
(genetics)
- Amino Acid Sequence
- Bacterial Proteins
(genetics)
- Diacylglycerol O-Acyltransferase
(genetics)
- Esterases
(genetics)
- Genes, Bacterial
- Glycogen
(biosynthesis)
- Lipase
(genetics)
- Lipids
(biosynthesis)
- Molecular Sequence Data
- Polyhydroxyalkanoates
(biosynthesis)
- Polyphosphates
(metabolism)
- Rhodococcus
(genetics, metabolism)
- Sequence Alignment
- Triglycerides
(biosynthesis)
- Waxes
(metabolism)
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