Moist Exposed Burn Ointment (MEBO) in partial thickness burns - a randomized, comparative open mono-center study on the efficacy of dermaheal (MEBO) ointment on thermal 2nd degree burns compared to conventional therapy.

Abstract

OBJECTIVE:

Wound healing in burn wounds presents a challenge in healthcare, and there is still a lack of alternatives in topical burn wound treatments. - The purpose of this study was to evaluate the efficacy of a new therapeutic ointment (MEBO) in the treatment of partial thickness burns.

METHODS:

40 patients received either topical treatment with Moist Exposed Burn Ointment (MEBO) or standard Flammazine treatment. All patients suffered from partial-thickness burn injuries (< 20% TBSA). Wounds were evaluated for 60 up to days regarding wound healing, water loss, inflammation, and pain alleviation.

RESULTS:

For transepidermal water loss, there was a difference of 2.3 gr/m2/h between MEBO, and Flammazine, favoring MEBO. However, this difference was not statistically significant (p=0.78). For all secondary efficacy parameter results were similar.

CONCLUSIONS:

This study showed that MEBO ointment for topical treatment of burn injuries presents an attractive alternative for the topical treatment of limited partial thickness thermal burns.

• Authors: T Hirsch, W Ashkar, O Schumacher, L Steinstraesser, G Ingianni, C C Cedidi
• Journal: European journal of medical research (Eur J Med Res) Vol. 13 Issue 11 Pg. 505-10 (Nov 24 2008) ISSN: 0949-2321 [Print] England
• PMID: 19073386 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Infective Agents, Local
• Ointments
• Water
• Silver Sulfadiazine

Topics

• Administration, Topical
• Adolescent
• Adult
• Aged
• Anti-Infective Agents, Local (administration & dosage)
• Bandages
• Burns (drug therapy)
• Female
• Humans
• Male
• Middle Aged
• Ointments (administration & dosage)
• Pain Threshold (drug effects)
• Severity of Illness Index
• Silver Sulfadiazine (administration & dosage)
• Treatment Outcome
• Water (metabolism)
• Wound Healing (drug effects)
• Young Adult