Abstract | OBJECTIVE: DESIGN: Retrospective case series. ANIMALS: 48 client-owned dogs in which PDH was diagnosed. PROCEDURES: RESULTS: 43 of 48 (90%) dogs had evidence of clinical improvement during the treatment period. In all dogs, treatment with ketoconazole resulted in significantly lower serum cortisol concentrations as measured before and after ACTH stimulation testing; 69% (33/48) of serum cortisol concentrations measured after ACTH stimulation were within the reference range. Serum ALP and ALT activities significantly decreased after treatment with ketoconazole. Survival time after diagnosis of PDH ranged from 2 to 61 months (mean, 26.9 months; median, 25 months). CONCLUSIONS AND CLINICAL RELEVANCE:
Ketoconazole was a safe and effective option for treating dogs with PDH. Additional research is needed to evaluate the effects of long-term treatment with ketoconazole on adrenal glands.
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Authors | Yu-Hsin Lien, Hui-Pi Huang |
Journal | Journal of the American Veterinary Medical Association
(J Am Vet Med Assoc)
Vol. 233
Issue 12
Pg. 1896-901
(Dec 15 2008)
ISSN: 0003-1488 [Print] United States |
PMID | 19072605
(Publication Type: Journal Article)
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Chemical References |
- Ketoconazole
- Hydrocortisone
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Topics |
- Adrenal Cortex Function Tests
(veterinary)
- Adrenocortical Hyperfunction
(drug therapy, mortality, veterinary)
- Animals
- Dog Diseases
(drug therapy, mortality)
- Dogs
- Female
- Hydrocortisone
(blood)
- Ketoconazole
(therapeutic use)
- Male
- Retrospective Studies
- Survival Analysis
- Treatment Outcome
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