[Trospium chloride in combined treatment of females with genital prolapse and overactive urinary bladder].

Abstract

The trial of efficacy of trospium chloride (TC) in a dose of 45 mg/day in females with overactive bladder (OAB) symptoms preserved after genital prolapse (GP) surgical correction included 28 females (age 55-82, mean age 68.07 +/- 12 years). GP was corrected by means of vaginal hysterectomy and anterior colporraphy. Treatment results were assessed 3 months after surgery basing on urine diary. Overall TC efficacy reached 82%. Symptoms attenuated in patients with and without detrusor overactivity: voiding frequency reduced by 31 and 24%, imperative voidings reduced by 26 and 8%, mean urine volume rose by 28 and 19%, respectively. Side effects were mild. TC demonstrated good efficacy in OAB patients, it noticeably improved quality of life.

• Authors: M e Shkol'nikov, E B Mazo, G G Krivoborodov, Iu E Dobrokhotova, M M Kaĭfadzhan, L V Fandeeva, R F Nurullin, M S Zhdanova
• Journal: Urologiia (Moscow, Russia : 1999) (Urologiia) 2008 Sep-Oct Issue 5 Pg. 16-9 ISSN: 1728-2985 [Print] Russia (Federation)
• PMID: 19069489 (Publication Type: English Abstract, Journal Article)

Chemical References

• Benzilates
• Nortropanes
• Parasympatholytics
• trospium chloride

Topics

• Aged
• Aged, 80 and over
• Benzilates
• Female
• Humans
• Hysterectomy, Vaginal (methods)
• Middle Aged
• Nortropanes (administration & dosage)
• Parasympatholytics (administration & dosage)
• Quality of Life
• Urinary Bladder, Overactive (therapy)
• Uterine Prolapse (therapy)