[Therapeutic strategies for advanced respectable esophageal cancer].

There are obvious differences in the clinical characteristics of patients with advanced respectable esophageal cancer between Japan and Western countries. In Japan, more than 90% of patients with esophageal cancer are histologically diagnosed with squamous cell carcinoma. On the other hand, the incidence of esophageal adenocarcinoma is rapidly increasing in the West. As a standard surgical approach, relatively invasive transthoracic extended esophagectomy has been established in Japan since the 1980s and has contributed to improved long-term survival of patients with squamous cell carcinoma. The current standard care for resectable stage II/III esophageal squamous cell carcinoma is neoadjuvant chemotherapy with 5-fluorouracil/cisplatin and radical esophagectomy based on the results of Japan Clinical Oncology Group trial 9907. In the West, relatively less invasive transhiatal esophagectomy with limited lymph node dissection has played a role in the multidisciplinary treatment of esophageal adenocarcinoma. Recently, a multimodal approach to esophageal cancer treatment including definitive chemoradiotherapy has been a focus of attention in both Japan and the West. For the further improvement of long-term survival of patients with esophageal cancer, the optimization of multimodal treatments and establishment of a global standard are essential.
AuthorsYuko Kitagawa
JournalNihon Geka Gakkai zasshi (Nihon Geka Gakkai Zasshi) Vol. 109 Issue 6 Pg. 333-7 (Nov 2008) ISSN: 0301-4894 [Print] Japan
PMID19068714 (Publication Type: Comparative Study, English Abstract, Journal Article)
  • Adenocarcinoma (pathology, therapy)
  • Carcinoma, Squamous Cell (pathology, therapy)
  • Chemotherapy, Adjuvant
  • Combined Modality Therapy
  • Esophageal Neoplasms (pathology, therapy)
  • Esophagectomy
  • Europe
  • Humans
  • Japan
  • Neoadjuvant Therapy
  • Neoplasm Staging
  • Radiotherapy, Adjuvant
  • Salvage Therapy
  • United States

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