Time- and dose-dependent induction of invasive urinary bladder cancers by N-ethyl-N-(4-hydroxybutyl)nitrosamine in B6C3F1 mice.

Abstract

A sequential investigation of N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) bladder carcinogenesis was performed in male B6C3F1 mice maintained ad libitum on tap water containing 0.025% EHBN for 4, 12, 20, 28 and 36 weeks. A total of 81 invasive tumors, comprising 55 squamous cell carcinomas (SCCs) (68%), 25 transitional cell carcinomas (TCCs) (31%) and 1 adenocarcinoma (1%) were found. Of these, 23 (22 SCCs and 1 TCC) demonstrated invasion to the prostate, 3 metastasized to the lung, and 2 spread by peritoneal seeding. The anaplastic grade and extent of invasion of the SCCs significantly exceeded those of the TCCs. The results suggested a histogenetic pathway from simple dysplasia through papillary or nodular dysplasia and/or carcinoma in situ to eventual development of invasive carcinomas.

• Authors: S Tamano, A Hagiwara, E Suzuki, M Okada, T Shirai, S Fukushima
• Journal: Japanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 82 Issue 6 Pg. 650-6 (Jun 1991) ISSN: 0910-5050 [Print] Japan
• PMID: 1906851 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinogens
• Butylhydroxybutylnitrosamine
• N-ethyl-N-(4-hydroxybutyl)nitrosamine

Topics

• Animals
• Butylhydroxybutylnitrosamine (analogs & derivatives, toxicity)
• Carcinogens (toxicity)
• Carcinoma in Situ (chemically induced, pathology)
• Carcinoma, Squamous Cell (chemically induced, pathology)
• Carcinoma, Transitional Cell (chemically induced, pathology)
• Dose-Response Relationship, Drug
• Epithelium (drug effects, pathology, ultrastructure)
• Male
• Mice
• Mice, Inbred Strains
• Neoplasm Invasiveness
• Time Factors
• Urinary Bladder (drug effects, pathology)
• Urinary Bladder Neoplasms (chemically induced, pathology)