[Promoting effect of constituents in plasma after oral administration of liuwei dihuangwan on proliferation of rat osteoblast].

Abstract

OBJECTIVE:

To elucidate the promoting effect of the constituents in plasma after oral administration of Liuwei Dihuangwan on proliferation of rat osteoblast.

METHOD:

To add the constituents in plasma after oral administration of Liuwei Dihuangwan with rational concentration into culture solution of rat osteoblast, later using MT method for determining the proliferation rate of rat osteoblast.

RESULT:

The Mixed group including morroniside, sweroside and loganin with different dose all significantly promoted proliferation of rat osteoblast.

CONCLUSION:

This study preliminarily elucidated the constituents such as morroniside, sweroside and loganin in plasma after oral administration of Liuwei Dihuangwan were main biological constituents which contributed to anti-osteoporosis bioactivity of Liuwei Dihuangwan.

• Authors: Hui Sun, Ning Zhang, Li-jing Li, Xi-jun Wang
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 33 Issue 17 Pg. 2161-4 (Sep 2008) ISSN: 1001-5302 [Print] China
• PMID: 19066066 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• Glucosides
• Glycosides
• Iridoid Glucosides
• Iridoids
• morroniside
• loganin
• sweroside

Topics

• Administration, Oral
• Animals
• Cell Proliferation (drug effects)
• Cells, Cultured
• Drugs, Chinese Herbal (administration & dosage)
• Glucosides (blood)
• Glycosides (blood)
• Iridoid Glucosides
• Iridoids (blood)
• Osteoblasts (cytology, drug effects)
• Plasma (chemistry, drug effects)
• Rats
• Rats, Wistar