Abstract | OBJECTIVES: METHODS: RESULTS: Six of 9 patients (67%) developed a grade 3 "burning" quality oral dysesthesia. These patients received at least 50 Gy (range 50-70 Gy) to the oral tongue. The patients without grade 3 oral dysesthesia received less than 50 Gy radiation to the oral tongue. The oral dysesthesia was exacerbated by the ingestion of neutral pH liquids such as water. Of the 6 patients, all eventually developed common toxicity criteria grade 3/4 mucositis; however, symptoms continued after resolution of the mucositis. Gabapentin ( Neurontin) was administered to 2 patients as a treatment for painful mucosal neuropathy. Both patients had near resolution of symptoms despite the evolution of oral mucositis. CONCLUSIONS:
|
Authors | Hadley Sharp, John C Morris, Carter Van Waes, David Gius, Theresa Cooley-Zgela, Anurag K Singh |
Journal | American journal of clinical oncology
(Am J Clin Oncol)
Vol. 31
Issue 6
Pg. 557-60
(Dec 2008)
ISSN: 1537-453X [Electronic] United States |
PMID | 19060587
(Publication Type: Clinical Trial, Phase I, Journal Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Amines
- Anticonvulsants
- Cyclohexanecarboxylic Acids
- Quinazolines
- gamma-Aminobutyric Acid
- Gabapentin
- Paclitaxel
- Gefitinib
|
Topics |
- Adult
- Aged
- Amines
(therapeutic use)
- Anticonvulsants
(therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects)
- Carcinoma, Squamous Cell
(drug therapy, pathology, radiotherapy, therapy)
- Combined Modality Therapy
- Cyclohexanecarboxylic Acids
(therapeutic use)
- Female
- Gabapentin
- Gefitinib
- Head and Neck Neoplasms
(drug therapy, pathology, radiotherapy, therapy)
- Humans
- Incidence
- Male
- Middle Aged
- Neoplasm Staging
- Paclitaxel
(administration & dosage)
- Paresthesia
(chemically induced, drug therapy)
- Prognosis
- Quinazolines
(administration & dosage)
- Radiation Injuries
(drug therapy, etiology)
- Radiotherapy
(adverse effects)
- Stomatitis
(chemically induced, drug therapy)
- gamma-Aminobutyric Acid
(therapeutic use)
|