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Photodynamic therapy of necrobiosis lipoidica--a multicenter study of 18 patients.

AbstractBACKGROUND:
Necrobiosis lipoidica (NL) is a granulomatous skin disease of unknown origin, and no reliably effective treatment option exists to handle this often disfiguring disease. Recently, a patient with long-lasting NL was reported to be cured by topical photodynamic therapy (PDT).
OBJECTIVE:
To evaluate the overall potential of PDT in the treatment of NL on the lower legs.
METHODS:
Retrospective study of 18 patients (aged 16-62 years) from 3 European university departments of dermatology treated with PDT for NL. Methyl aminolevulinate or 5-aminolevulinic acid were used as topically applied photosensitizers. Illumination followed with red light-emitting diode light.
RESULTS:
Complete response was seen in 1/18 patients after 9 PDT cycles, and partial response in 6/18 patients (2-14 PDT cycles) giving an overall response rate of 39% (7/18).
CONCLUSION:
Although almost 40% of the cases showed some degree of response, PDT cannot currently be recommended as first-line therapy of NL. Subpopulations of therapy-resistant NL patients may, however, benefit from PDT.
AuthorsC Berking, J Hegyi, P Arenberger, T Ruzicka, G B E Jemec
JournalDermatology (Basel, Switzerland) (Dermatology) Vol. 218 Issue 2 Pg. 136-9 ( 2009) ISSN: 1421-9832 [Electronic] Switzerland
PMID19060464 (Publication Type: Journal Article, Multicenter Study)
CopyrightCopyright (c) 2008 S. Karger AG, Basel.
Chemical References
  • Photosensitizing Agents
  • methyl 5-aminolevulinate
  • Aminolevulinic Acid
Topics
  • Administration, Cutaneous
  • Adolescent
  • Adult
  • Aminolevulinic Acid (administration & dosage, analogs & derivatives)
  • Czech Republic
  • Denmark
  • Female
  • Germany
  • Humans
  • Leg (pathology)
  • Male
  • Middle Aged
  • Necrobiosis Lipoidica (drug therapy, pathology)
  • Photochemotherapy (methods)
  • Photosensitizing Agents (administration & dosage)
  • Retrospective Studies
  • Treatment Outcome

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