Abstract | BACKGROUND: METHODS: This study comprised 141 unrelated patients who strictly met the DSM-IV criteria for schizophrenia and 115 control subjects. All subjects were of Korean ethnicity. Serotonin transporter intron 2 VNTR polymorphism (5-HTTVNTR) and serotonin transporter linked polymorphic region polymorphism (5-HTTLPR) were analyzed in schizophrenia patients and control subjects. The Positive and Negative Symptom Scale (PANSS) was used at baseline and 6 weeks after atypical antipsychotic treatment to evaluate the clinical symptoms. Body mass index (BMI), the Barnes Akathisia Rating Scale (BARS), the Simpson-Angus Rating Scale (EPS) for adverse effect and the Calgary Depression rating Scale for Schizophrenia (CDSS) were measured. RESULTS: There were no significant differences in the frequency of genotypes between schizophrenia patients and control subjects. There were no significant differences in PANSS scores before treatment according to the serotonin transporter genotypes. Treatment response after atypical antipsychotics did not differ among the genotypes. No difference was shown among the genotypes for the scales in adverse effects and depression (BMI, BARS, EPS, CDSS). CONCLUSIONS:
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Authors | Hwa-Young Lee, Dai-Jin Kim, Heon-Jeong Lee, Jung-Eun Choi, Yong-Ku Kim |
Journal | Progress in neuro-psychopharmacology & biological psychiatry
(Prog Neuropsychopharmacol Biol Psychiatry)
Vol. 33
Issue 2
Pg. 276-80
(Mar 17 2009)
ISSN: 0278-5846 [Print] England |
PMID | 19059448
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antipsychotic Agents
- Serotonin Plasma Membrane Transport Proteins
- DNA
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Topics |
- Adult
- Age of Onset
- Antipsychotic Agents
(therapeutic use)
- Body Mass Index
- DNA
(genetics)
- Female
- Gene Frequency
- Genotype
- Humans
- Korea
(epidemiology)
- Male
- Polymorphism, Genetic
(genetics)
- Psychiatric Status Rating Scales
- Psychomotor Agitation
(psychology)
- Reverse Transcriptase Polymerase Chain Reaction
- Schizophrenia
(drug therapy, epidemiology, genetics)
- Schizophrenic Psychology
- Serotonin Plasma Membrane Transport Proteins
(genetics)
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