Long-term results of stereotactic proton beam radiotherapy for acoustic neuromas.

Abstract

BACKGROUND AND PURPOSE:

A retrospective study evaluating the role of hypofractionated stereotactic proton beam therapy for acoustic neuromas.

MATERIALS AND METHODS:

The data of 51 patients treated with hypofractionation (3 fractions) and followed up for a minimum of 2 years, were analyzed. Mean dose prescribed to ICRU reference point (isocenter) was 26 cobalt gray equivalent (CGyE) in 3 fractions. Mean minimum tumor dose was 21.4 CGyE/3. Cranial nerve functions were evaluated clinically. Serial MR Scans were used to evaluate local control.

RESULTS:

With a mean clinical and radiological follow-up of 72 and 60 months respectively, the 5-year results showed a 98% local control, with a hearing preservation of 42%, a facial nerve preservation of 90.5% and a trigeminal nerve preservation of 93%.

CONCLUSION:

For those patients harboring large acoustic neuromas that are inoperable, hypofractionated stereotactic proton beam offers long-term control with minimal side-effects.

• Authors: Frederik J A I Vernimmen, Zainab Mohamed, Jacobus P Slabbert, Jennifer Wilson
• Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (Radiother Oncol) Vol. 90 Issue 2 Pg. 208-12 (Feb 2009) ISSN: 0167-8140 [Print] Ireland
• PMID: 19054586 (Publication Type: Journal Article)

Chemical References

• Protons

Topics

• Adult
• Aged
• Aged, 80 and over
• Dose Fractionation, Radiation
• Facial Nerve Diseases (etiology)
• Female
• Hearing
• Humans
• Male
• Middle Aged
• Neuroma, Acoustic (surgery)
• Protons
• Radiosurgery (adverse effects)
• Radiotherapy Dosage
• Trigeminal Nerve
• Trigeminal Nerve Diseases (etiology)
• Young Adult