Heterogeneity of the breakpoint localization in malignant cells with a 9p11 chromosomal abnormality.

Abstract

The p11 band of the short arm of chromosome 9 is involved in various cytogenetic alterations occurring in several malignant diseases. Using probes isolated from the 9p11 band in the study of a case of alpha-heavy-chain disease (MAL) with t(9;14)(p11;q32), we studied the DNA from seven malignant cell samples, including four cases of acute lymphoblastic leukemia with tdic(9;12)(p11;p12). Using pulsed-field electrophoresis analysis we demonstrated that the breakpoints were 3-300 kb distant from the original MAL breakpoint without clustering within the subset of leukemias with the tdic(9;12).

• Authors: P Pellet, J Hillion, A J Carroll, W M Crist, J C Brouet, A Tsapis
• Journal: Leukemia (Leukemia) Vol. 5 Issue 6 Pg. 468-72 (Jun 1991) ISSN: 0887-6924 [Print] England
• PMID: 1905369 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Immunoglobulin alpha-Chains

Topics

• Chromosome Aberrations
• Chromosome Fragility
• Chromosome Mapping
• Chromosomes, Human, Pair 12
• Chromosomes, Human, Pair 14
• Chromosomes, Human, Pair 9
• Electrophoresis (methods)
• Heavy Chain Disease (genetics)
• Humans
• Immunoglobulin alpha-Chains
• Leukemia-Lymphoma, Adult T-Cell (genetics)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (genetics)
• Translocation, Genetic