Abstract | AIMS: METHODS: Of 55 patients with colorectal cancer, 20 had no metastasis and the other 35 had distant metastasis. A strong expression was classified as positive, while weak to moderate or no expression was negative by immunohistochemistry. RESULTS: Of the six 5-FU-related enzymes, the numbers of patients with expression of dUTPase (54% versus 15%; p = 0.005), TK (26% versus 0%; p = 0.019) and DPD (17% versus 45%; p = 0.033) were significantly different in those with primary tumours with metastasis compared with those with non- metastasis, respectively. The altered expression of OPRT (34.3%), TS (40.0%) and dUTPase (42.9%) was significantly greater from primary to metastasis among the 35 patients with metastasis. By contrast, the expression of OPRT, TS and dUTPase was decreased in 6, 5 and 7 patients, respectively, in metastatic sites. CONCLUSIONS:
|
Authors | A Kawahara, Y Akagi, S Hattori, T Mizobe, K Shirouzu, M Ono, T Yanagawa, M Kuwano, M Kage |
Journal | Journal of clinical pathology
(J Clin Pathol)
Vol. 62
Issue 4
Pg. 364-9
(Apr 2009)
ISSN: 1472-4146 [Electronic] England |
PMID | 19052026
(Publication Type: Journal Article)
|
Chemical References |
- Antimetabolites, Antineoplastic
- Biomarkers, Tumor
- Pyrophosphatases
- dUTP pyrophosphatase
- Fluorouracil
|
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Antimetabolites, Antineoplastic
(metabolism)
- Biomarkers, Tumor
(metabolism)
- Colorectal Neoplasms
(enzymology, pathology, surgery)
- Female
- Fluorouracil
(metabolism)
- Humans
- Intestinal Mucosa
(enzymology)
- Liver Neoplasms
(enzymology, secondary)
- Lung Neoplasms
(enzymology, secondary)
- Male
- Middle Aged
- Neoplasm Staging
- Prognosis
- Pyrophosphatases
(metabolism)
- Young Adult
|