Prognostic factors and adjuvant therapy in uterine carcinosarcoma.

Abstract

PURPOSE OF INVESTIGATION:

The objective of this retrospective study was to investigate prognostic variables and impact of adjuvant therapy in uterine carcinosarcoma.

METHODS:

The clinical information and pathological confirmation were reviewed for cases with uterine carcinosarcoma from 1984 to 2005. A total of 45 patients were eligible for analysis.

RESULTS:

The median follow-up for survivors was 84 months. Five-year overall survival and progression-free survival (PFS) rates were 36.5% and 33.8%, respectively for Stage I-IV. Distant site metastasis with/without pelvic failure occurred in 83.3% of those with recurrence/progression. By multivariate analysis, older age (p = 0.001) and more than half of myometrial invasion (p = 0.002) were significant predictors of death, while only myometrial invasion (p = 0.022) was significantly associated with PFS. Stratified analyses demonstrated a monotonic trend of chemotherapy or chemoradiation to decrease death.

CONCLUSIONS:

Our results suggested that age and depth of myometrial invasion were significant prognostic factors, and chemotherapy or chemoradiation seemed to be beneficial for uterine carcinosarcoma.

• Authors: T I Wu, K H Hsu, H J Huang, S Hsueh, H H Chou, C S Tsai, K C Ho, A Chao, T C Chang, C H Lai
• Journal: European journal of gynaecological oncology (Eur J Gynaecol Oncol) Vol. 29 Issue 5 Pg. 483-8 ( 2008) ISSN: 0392-2936 [Print] Singapore
• PMID: 19051818 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Carcinosarcoma (mortality, pathology, therapy)
• Chemotherapy, Adjuvant
• Disease-Free Survival
• Female
• Humans
• Middle Aged
• Myometrium (pathology)
• Neoplasm Invasiveness
• Prognosis
• Radiotherapy, Adjuvant
• Retrospective Studies
• Survival Rate
• Uterine Neoplasms (mortality, pathology, therapy)