[Imidazoles in the treatment of ocular mycoses].

Abstract

The use of a new class of broad spectrum antifungal drugs i.e. imidazoles and in particular ketoconazole in treatment of severe affections of the eye such as mycoses is described. The clinical trials included 40 patients with various forms of mycosis: mycotic canaliculitis (6 patients), mycotic blepharitis (4 patients), mycotic conjunctivitis (7 patients), keratomycosis (17 patients) and mycotic endophthalmitis (6 patients). Ketoconazole was used in the form of tablets and instillations. The combined treatment included nonsteroid antiinflammatory drugs and antibacterial agents. The clinical trials showed that ketoconazole had pronounced antifungal activity and was rather efficient in treatment of ocular mycoses. Its broad spectrum and low toxicity were recorded.

• Authors: Iu F Maĭchuk, N A Lapshina, U V Diadina
• Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 36 Issue 1 Pg. 45-6 (Jan 1991) ISSN: 0235-2990 [Print] Russia (Federation)
• Vernacular Title: Imidazoly v lechenii mikozov glaza.
• PMID: 1905126 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Ophthalmic Solutions
• Ketoconazole

Topics

• Administration, Oral
• Aspergillosis (drug therapy)
• Candidiasis (drug therapy)
• Eye Infections, Fungal (drug therapy)
• Humans
• Ketoconazole (administration & dosage)
• Ophthalmic Solutions
• Penicillium chrysogenum