HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Coenzyme Q10 and vitamin E deficiency in Friedreich's ataxia: predictor of efficacy of vitamin E and coenzyme Q10 therapy.

AbstractBACKGROUND AND PURPOSE:
A pilot study of high dose coenzyme Q(10) (CoQ(10))/vitamin E therapy in Friedreich's ataxia (FRDA) patients resulted in significant clinical improvements in most patients. This study investigated the potential for this treatment to modify clinical progression in FRDA in a randomized double blind trial.
METHODS:
Fifty FRDA patients were randomly divided into high or low dose CoQ(10)/ vitamin E groups. The change in International Co-operative Ataxia Ratings Scale (ICARS) was assessed over 2 years as the primary end-point. A post hoc analysis was made using cross-sectional data.
RESULTS:
At baseline serum CoQ(10) and vitamin E levels were significantly decreased in the FRDA patients (P < 0.001). During the trial CoQ(10) and vitamin E levels significantly increased in both groups (P < 0.01). The primary and secondary end-points were not significantly different between the therapy groups. When compared to cross-sectional data 49% of all patients demonstrated improved ICARS scores. This responder group had significantly lower baseline serum CoQ(10) levels.
CONCLUSIONS:
A high proportion of FRDA patients have a decreased serum CoQ(10) level which was the best predictor of a positive clinical response to CoQ(10)/vitamin E therapy. Low and high dose CoQ(10)/vitamin E therapies were equally effective in improving ICARS scores.
AuthorsJ M Cooper, L V P Korlipara, P E Hart, J L Bradley, A H V Schapira
JournalEuropean journal of neurology (Eur J Neurol) Vol. 15 Issue 12 Pg. 1371-9 (Dec 2008) ISSN: 1468-1331 [Electronic] England
PMID19049556 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Antioxidants
  • Electron Transport Chain Complex Proteins
  • Ubiquinone
  • Vitamin E
  • coenzyme Q10
Topics
  • Adolescent
  • Adult
  • Antioxidants (administration & dosage)
  • Dose-Response Relationship, Drug
  • Electron Transport Chain Complex Proteins (genetics, metabolism)
  • Endpoint Determination
  • Energy Metabolism (drug effects, physiology)
  • Female
  • Friedreich Ataxia (drug therapy, metabolism, physiopathology)
  • Humans
  • Male
  • Mitochondria (genetics, metabolism)
  • Muscle, Striated (metabolism, physiopathology)
  • Oxidative Stress (drug effects, physiology)
  • Predictive Value of Tests
  • Treatment Outcome
  • Ubiquinone (administration & dosage, analogs & derivatives, blood, deficiency)
  • Up-Regulation (drug effects, physiology)
  • Vitamin E (administration & dosage)
  • Vitamin E Deficiency (blood, drug therapy, physiopathology)
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: