Ni/Ni oxides nanoparticles with potential biomedical applications obtained by displacement of a nickel-organometallic complex.

Abstract

A new synthesis and stabilization method was developed for paramagnetic nanoparticles composed of nickel and nickel oxides. Nickel/nickel oxides nanoparticles were synthesized by a method based on ligand displacement of bis(1,5-cyclooctadiene)-nickel(0), zerovalent organometallic precursor and simultaneous formation of a thiourea inclusion compound. Nickel/nickel oxides nanoparticles were stabilized with the amphipathic peptide H2N-Cys-Leu-Pro-Phe-Phe-Asp-NH2 having H2N-Leu-Pro-Phe-Phe-Asp-NH2 a peptide with potential properties for Alzheimer's disease therapy. The inclusion compound formed after displacement was characterized by X-ray powder diffraction, and nickel/nickel oxides nanoparticles were characterized using transmission electron microscopy, atomic force microscopy, UV-Visible spectroscopy, X-ray photoelectron spectroscopy, and superconducting quantum interference device magnetometry. In addition, a cell viability assay in primary rat hippocampal neurons was carried out.

• Authors: Saddys Rodríguez-Llamazares, Juan Merchán, Ivonne Olmedo, Héctor Pablo Marambio, Juan Pablo Muñoz, Paul Jara, Juan Carlos Sturm, Boris Chornik, Octavio Peña, Nicolás Yutronic, Marcelo Javier Kogan
• Journal: Journal of nanoscience and nanotechnology (J Nanosci Nanotechnol) Vol. 8 Issue 8 Pg. 3820-7 (Aug 2008) ISSN: 1533-4880 [Print] United States
• PMID: 19049136 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• H2N-Leu-Pro-Phe-Phe-Asp-NH2
• Oligopeptides
• Nickel
• nickel monoxide

Topics

• Animals
• Cell Line
• Cell Survival (drug effects)
• Drug Delivery Systems
• Drug Stability
• Hippocampus (cytology)
• In Vitro Techniques
• Metal Nanoparticles (chemistry)
• Neurons (cytology, drug effects)
• Nickel (chemistry)
• Oligopeptides (chemistry, pharmacology)
• Rats
• Rats, Sprague-Dawley