Prognostic significance of serum S100B protein in high-risk surgically resected melanoma patients participating in Intergroup Trial ECOG 1694.

Abstract

PURPOSE:

We evaluated adjuvant trial E1694 to more precisely define the prognostic significance of serum S100B in patients with high-risk resected melanoma.

PATIENTS AND METHODS:

Sera from 670 E1694 patients banked at baseline and three additional time points were tested for S100B protein using chemiluminescence.

RESULTS:

S100B testing results showed that the higher the S100B level is, the higher the risk of relapse and death, regardless of the cutoff value. Univariate analysis showed that baseline S100B > or = 0.15 microg/L is significantly correlated with overall survival (OS; P = .01). Multivariate analysis was performed adjusting for significant prognostic factors (ulceration and lymph node status) and treatment. Baseline S100B was a significant prognostic factor for survival (hazard ratio = 1.39; 95% CI, 1.01 to 1.92; P = .043). S100B values measured at later time points over 1 year were also demonstrated to be significant prognostic factors for relapse-free survival (RFS) and OS. Lower S100B values at baseline and during follow-up were associated with longer survival. A changing S100B from low at baseline to high on follow-up seemed to be associated with the worst RFS and OS.

CONCLUSION:

For patients with high-risk surgically resected melanoma, a high baseline or increasing serum S100B is an independent prognostic marker of risk for mortality that may allow us to refine the application of adjuvant therapy in the future.

• Authors: Ahmad A Tarhini, Joseph Stuckert, Sandra Lee, Cindy Sander, John M Kirkwood
• Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (J Clin Oncol) Vol. 27 Issue 1 Pg. 38-44 (Jan 01 2009) ISSN: 1527-7755 [Electronic] United States
• PMID: 19047287 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Nerve Growth Factors
• S100 Calcium Binding Protein beta Subunit
• S100 Proteins
• S100B protein, human
• L-Lactate Dehydrogenase

Topics

• Adult
• Aged
• Aged, 80 and over
• Female
• Humans
• L-Lactate Dehydrogenase (blood)
• Male
• Melanoma (blood, mortality, surgery)
• Middle Aged
• Multivariate Analysis
• Nerve Growth Factors (blood)
• Prognosis
• S100 Calcium Binding Protein beta Subunit
• S100 Proteins (blood)