Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer.

Abstract

The effects of fullerenol C60(OH)24 (Frl) at doses of 25, 50, and 100mg/kg/week (for a time-span of 3 weeks) on heart and liver tissue after doxorubicin (Dox)-induced toxicity in rats with colorectal cancer were investigated. In the present study, we used an in vivo Wistar male rat model to explore whether Frl could protect against Dox-induced (1.5mg/kg/week for 3 weeks) chronic cardio- and hepato- toxicity and compared the effect with a well-known antioxidant, vitamin C (100mg/kg/week for 3 weeks). According to macroscopic, microscopic, hematological, biochemical, physiological, pharmacological, and pharmacokinetic results, we confirmed that, at all examined doses, Frl exhibits a protective influence on the heart and liver tissue against chronic toxicity induced by Dox.

• Authors: Rade Injac, Martina Perse, Manica Cerne, Nejka Potocnik, Natasa Radic, Biljana Govedarica, Aleksandar Djordjevic, Anton Cerar, Borut Strukelj
• Journal: Biomaterials (Biomaterials) Vol. 30 Issue 6 Pg. 1184-96 (Feb 2009) ISSN: 1878-5905 [Electronic] Netherlands
• PMID: 19046599 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cardiotoxins
• Enzymes
• Fullerenes
• Protective Agents
• fullerenol
• Malondialdehyde
• Doxorubicin
• Glutathione Disulfide

Topics

• Abdominal Cavity (pathology)
• Animals
• Body Weight (drug effects)
• Cardiotoxins (toxicity)
• Colorectal Neoplasms (blood, enzymology, pathology)
• Doxorubicin (toxicity)
• Electrocardiography
• Enzymes (blood)
• Fullerenes (pharmacokinetics, pharmacology)
• Glutathione Disulfide (metabolism)
• Heart (drug effects)
• Hemodynamics (drug effects)
• Liver (drug effects, pathology)
• Male
• Malondialdehyde (metabolism)
• Myocardium (pathology)
• Oxidation-Reduction (drug effects)
• Oxidative Stress (drug effects)
• Protective Agents (pharmacology)
• Rats
• Rats, Wistar