Abstract | OBJECTIVES: METHODS: Two hundred fifty two IC/PBS patients (25 men, 227 women; 18-69 years old), who had failed other treatments, took four CystoProtek capsules /day (mg/ capsule: glucosamine sulfate, 120; chondroitin sulfate, 150; hyaluronate sodium, 10; quercetin, 150; rutin, 20). Symptoms were evaluated using a visual analogue scale (VAS) (severity range from 1-10) before and after treatment (< 6, 6-12 or > 12 months). The women were divided into two severity groups--a more severe A group with a baseline mean VAS score greater than or equal to 5 and a less severe B group with a mean score < 5. RESULTS: Male patients (55.72 +/- 9.53 years, n = 25) had a mean VAS score at baseline of 7.6 +/- 1.63 which fell 51.8% to 3.94 +/- 2.46 (p < 0.0001) after 12.46 +/- 8.76 months of treatment. The women (n = 227) experienced a 48.8% reduction in the mean VAS score (p < 0.0001) after 11.2 +/- 8.7 months. The mean VAS score in Group A (49.72 +/- 11.39 years, n = 207) fell 52.1% from 7.91 +/- 1.55 to 3.79 +/- 2.37 (p < 0.0001) after 11.06 +/- 8.18 months and in Group B (52.40 +/- 10.19 years, n = 20) fell 43.5% from 3.15 +/- 0.92 to 1.78 +/- 1.63 (p = 0.013) after 10.10 +/- 5.80 months. Patients in Group A and B were further subdivided into Groups A1, B1 (> 12 months), A2, B2 (6-12 months) and A3, B3 (< 6 months treatment); improvement was statistically significant in all the more severe Group A treatment duration subgroups. CONCLUSIONS: Dietary supplements targeting the bladder GAGs ( chondroitin, glucosamine, hyaluronate) and bladder inflammation ( quercetin, rutin) are useful in the treatment of refractory IC/PBS. Prospective randomized trials of such supplements are warranted in both treatment refractory and treatment naïve patients.
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Authors | T C Theoharides, D Kempuraj, S Vakali, G R Sant |
Journal | The Canadian journal of urology
(Can J Urol)
Vol. 15
Issue 6
Pg. 4410-4
(Dec 2008)
ISSN: 1195-9479 [Print] Canada |
PMID | 19046494
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drug Combinations
- chondroitin sulfate, sodium hyaluronate drug combination
- Hyaluronic Acid
- Chondroitin Sulfates
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Topics |
- Adolescent
- Adult
- Aged
- Chondroitin Sulfates
(therapeutic use)
- Cystitis, Interstitial
(diet therapy)
- Dietary Supplements
- Drug Combinations
- Female
- Humans
- Hyaluronic Acid
(therapeutic use)
- Male
- Middle Aged
- Young Adult
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